Abstract
The autotransporters, a family of secreted proteins from Gram-negative bacteria, possess an overall unifying structure comprising three functional domains: the amino-terminal leader sequence, the secreted mature protein (passenger domain) and a carboxy-terminal (beta-) domain that forms a beta-barrel pore to allow secretion of the passenger protein. Members of this family have been implicated as important or putative virulence factors in many Gram-negative pathogens.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adhesins, Bacterial / chemistry
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Adhesins, Bacterial / physiology*
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Amino Acid Sequence
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism
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Carrier Proteins / physiology*
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Gram-Negative Bacteria / metabolism*
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Molecular Sequence Data
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Phylogeny
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Sequence Homology, Amino Acid
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Serine Endopeptidases / chemistry
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Serine Endopeptidases / genetics
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Serine Endopeptidases / metabolism
Substances
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Adhesins, Bacterial
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Carrier Proteins
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Serine Endopeptidases
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IgA-specific serine endopeptidase