In vitro activities of 15 antimicrobial agents against clinical isolates of South African enterococci

Antimicrob Agents Chemother. 1998 Oct;42(10):2752-5. doi: 10.1128/AAC.42.10.2752.

Abstract

The activities of a panel of currently available antibiotics and the investigational agents LY 333328, linezolid, CL 331,002, CL 329,998, moxifloxacin (BAY 12-8039), trovafloxacin, and quinupristin-dalfopristin against 274 clinical isolates of enterococci were determined. No vancomycin resistance or beta-lactamase production was observed. Except for 12 isolates (all non-Enterococcus faecalis) showing reduced susceptibility to quinupristin-dalfopristin (MIC, >/=4 microg/ml), the new agents exhibited promising in vitro antienterococcal activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Microbial
  • Enterococcus / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • South Africa

Substances

  • Anti-Bacterial Agents