Abstract
Prophylactic treatment of Rocky Mountain spotted fever with a single dose of oxytetracycline was investigated in guinea pigs. Disease was prevented when treatment was administered shortly before expected onset. Relapses occurred when treatment preceded expected onset by 48 h or more.
MeSH terms
-
Agglutination Tests
-
Animals
-
Antibodies, Bacterial / biosynthesis
-
Guinea Pigs
-
Injections, Intramuscular
-
Lymphocyte Activation
-
Male
-
Oxytetracycline / administration & dosage*
-
Recurrence
-
Rickettsia rickettsii / immunology
-
Rocky Mountain Spotted Fever / immunology
-
Rocky Mountain Spotted Fever / prevention & control*
-
Time Factors
Substances
-
Antibodies, Bacterial
-
Oxytetracycline