Abstract
With the emergence of staphylococci as important hospital pathogens, administration of vancomycin has increased dramatically. Economic and other factors have led to the development of once-daily dosing protocols to simplify and standardize the administration of antibiotics. A patient with Staphylococcus aureus prosthetic valve endocarditis and normal renal function failed therapy with vancomycin once/day. The infection was cured when the regimen was changed to the conventional 12-hour dosing interval.
MeSH terms
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Adult
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / therapeutic use
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Drug Administration Schedule
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / etiology
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Heart Valve Prosthesis / adverse effects*
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Humans
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Male
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / etiology
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / etiology
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Vancomycin / administration & dosage*
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Vancomycin