In vitro activity of a new pneumocandin antifungal, L-743,872, against azole-susceptible and -resistant Candida species

J A Vazquez; M Lynch; D Boikov; J D Sobel

doi:10.1128/AAC.41.7.1612

In vitro activity of a new pneumocandin antifungal, L-743,872, against azole-susceptible and -resistant Candida species

Antimicrob Agents Chemother. 1997 Jul;41(7):1612-4. doi: 10.1128/AAC.41.7.1612.

Authors

J A Vazquez¹, M Lynch, D Boikov, J D Sobel

Affiliation

¹ Department of Medicine, Wayne State University School of Medicine, and Detroit Veterans Administration Medical Center, Michigan, USA.

Abstract

The in vitro activity of a new pneumocandin, L-743,872, was evaluated with 108 strains of Candida and compared with the activities of various antifungals. L-743,872 demonstrated the best activity against azole-susceptible and -resistant strains of C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, and C. kefyr and less activity against C. krusei, C. lusitaniae, and C. guilliermondii.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Antifungal Agents / pharmacology*
Azoles / pharmacology*
Candida / drug effects*
Caspofungin
Drug Resistance
Echinocandins
Lipopeptides
Microbial Sensitivity Tests
Peptides*
Peptides, Cyclic*

Substances

Anti-Bacterial Agents
Antifungal Agents
Azoles
Echinocandins
Lipopeptides
Peptides
Peptides, Cyclic
Caspofungin