Treatment of enteric fever with pefloxacin for 7 days versus 5 days: a randomized clinical trial

Antimicrob Agents Chemother. 1996 Dec;40(12):2898-900. doi: 10.1128/AAC.40.12.2898.

Abstract

In this prospective study of enteric fever, 22 patients received 400 mg of pefloxacin twice daily for 5 days (group A) and 24 received 400 mg of pefloxacin twice daily for 7 days (group B). Causative microorganisms were Salmonella typhi (8 in group A, 11 in group B) and Salmonella paratyphi B (14 in group A, 13 in group B). The clinical cure and bacterial eradication rates were 96% (21 of 22) in group A and 100% in group B. In conclusion, 5-day oral administration of pefloxacin was as effective as 7-day treatment of enteric fever caused by Salmonella spp.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • 4-Quinolones*
  • Adolescent
  • Adult
  • Aged
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / therapeutic use*
  • Drug Administration Schedule
  • Female
  • Fluoroquinolones*
  • Humans
  • Male
  • Middle Aged
  • Paratyphoid Fever / drug therapy*
  • Pefloxacin
  • Prospective Studies
  • Quinolones / administration & dosage
  • Quinolones / therapeutic use*
  • Salmonella paratyphi B*
  • Treatment Outcome
  • Typhoid Fever / drug therapy*

Substances

  • 4-Quinolones
  • Anti-Infective Agents
  • Fluoroquinolones
  • Quinolones