Abstract
Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracycline was detected only in certain strains.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / metabolism*
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Anti-Bacterial Agents / pharmacology
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Chloramphenicol / metabolism
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Chloramphenicol / pharmacology
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Enterococcus faecalis / drug effects
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Enterococcus faecalis / metabolism*
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Enterococcus faecium / drug effects
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Enterococcus faecium / metabolism*
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Microbial Sensitivity Tests
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Norfloxacin / metabolism
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Norfloxacin / pharmacology
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Tetracycline / metabolism
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Tetracycline / pharmacology
Substances
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Anti-Bacterial Agents
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Chloramphenicol
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Tetracycline
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Norfloxacin