Abstract
Two oxazolidinones (U100592 and U100766), trovafloxacin, and a streptogramin combination (dalfopristin-quinupristin) were highly active in vitro against Staphylococcus aureus and Staphylococcus epidermidis, including methicillin-resistant strains. Trovafloxacin was more active than ciprofloxacin. Time-kill synergy studies demonstrated indifference for the oxazolidinones combined with vancomycin and rifampin against methicillin-resistant staphylococci. Spontaneous resistance was observed with all agents.
MeSH terms
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Acetamides / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Microbial
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Drug Synergism
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Fluoroquinolones*
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Humans
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Linezolid
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Microbial Sensitivity Tests
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Naphthyridines / pharmacology*
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Oxazoles / pharmacology*
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Oxazolidinones*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus epidermidis / drug effects*
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Time Factors
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Virginiamycin / pharmacology*
Substances
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Acetamides
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Anti-Bacterial Agents
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Fluoroquinolones
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Naphthyridines
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Oxazoles
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Oxazolidinones
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Virginiamycin
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quinupristin-dalfopristin
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trovafloxacin
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eperezolid
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Linezolid