Transient aplastic anemia caused by parvovirus B19 infection in a heart transplant recipient

G A Bergen; P E Sakalosky; J T Sinnott

Transient aplastic anemia caused by parvovirus B19 infection in a heart transplant recipient

J Heart Lung Transplant. 1996 Aug;15(8):843-5.

Authors

G A Bergen¹, P E Sakalosky, J T Sinnott

Affiliation

¹ University of South Florida College of Medicine, Division of Infectious Diseases and Tropical Medicine, Tampa, USA.

PMID: 8878766

Abstract

Parvovirus B19 infection in the transplant patient is rarely reported, although cases have occurred in patients with bone marrow, liver, and renal transplants and in children undergoing heart transplantation. We present the first reported case of an orthotopic heart transplant recipient with aplastic crisis caused by parvovirus B19. The infection was diagnosed by bone marrow biopsy, confirmed by serologic studies and polymerase chain reaction, and successfully treated with intravenous immunoglobulin.

Publication types

Case Reports

MeSH terms

Anemia, Aplastic / drug therapy
Anemia, Aplastic / pathology
Anemia, Aplastic / virology*
Biopsy
Bone Marrow / pathology
DNA, Viral / analysis
Female
Heart Transplantation*
Humans
Immunoenzyme Techniques
Immunoglobulin M / immunology
Immunoglobulins, Intravenous / therapeutic use
Middle Aged
Parvoviridae Infections / complications*
Parvoviridae Infections / drug therapy
Parvoviridae Infections / pathology
Parvovirus B19, Human / genetics
Parvovirus B19, Human / immunology
Polymerase Chain Reaction

Substances

DNA, Viral
Immunoglobulin M
Immunoglobulins, Intravenous