Abstract
The new oxazolidinone antimicrobial agents U100592 and U100766 demonstrated good in vitro inhibitory activity against clinical strains of Staphylococcus aureus and Staphylococcus epidermidis regardless of methicillin susceptibility. Both agents appeared bacteriostatic by time-kill analysis. Stable resistance to low multiples of the MIC of either drug could be produced only in methicillin-resistant S. aureus.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Microbial
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Linezolid
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Methicillin Resistance
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Microbial Sensitivity Tests
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Nafcillin / pharmacology
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Oxazoles / pharmacology*
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Oxazolidinones*
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Penicillins / pharmacology
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Staphylococcus aureus / drug effects*
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Staphylococcus epidermidis / drug effects*
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Time Factors
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Vancomycin / pharmacology
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazoles
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Oxazolidinones
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Penicillins
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Nafcillin
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Vancomycin
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eperezolid
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Linezolid