Development of novel vaccines against anthrax in man

J Biotechnol. 1996 Jan 26;44(1-3):155-60. doi: 10.1016/0168-1656(95)00092-5.

Abstract

It has been shown that antianthrax immunity induced by the novel vaccine proposed has not only antitoxic, but also antispore character. The whole complex of antigens, namely surface spore antigens, surface antigens of cell wall and toxin components is required for the induction of strong and stable immunity against anthrax. The STI-1 vaccine strain with introduced resistance to several antibiotics seems to be promising for prophylaxis and treatment of anthrax in case of emergency, especially if antibiotic pretreatment could be expected. The technology for submerged cultivation of Bacillus anthracis vaccine strain and for the development of an anthrax vaccine to be used in human medicine is proposed on the basis of the conception of the immunogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthrax / immunology*
  • Anthrax / prevention & control
  • Anthrax / veterinary
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Bacterial Agents / toxicity
  • Antibodies, Bacterial / biosynthesis
  • Antibody Formation
  • Bacillus anthracis / drug effects
  • Bacillus anthracis / immunology
  • Bacterial Vaccines*
  • Cattle
  • Cattle Diseases
  • Cricetinae
  • Doxycycline / therapeutic use
  • Drug Resistance, Microbial
  • Humans
  • Immunization
  • Pilot Projects
  • Rabbits
  • gamma-Globulins / administration & dosage
  • gamma-Globulins / immunology

Substances

  • Anti-Bacterial Agents
  • Antibodies, Bacterial
  • Bacterial Vaccines
  • gamma-Globulins
  • Doxycycline