Abstract
Infections caused by entercocci have become increasingly difficult to treat because these bacteria are becoming increasingly resistant to commonly used antibiotics such as ampicillin, gentamicin and vancomycin. A consensus for an optimal therapy of enterococcal infections caused by resistant isolates has not yet been determined. We present a patient with prolonged enterococcal sepsis in whom a combination of ampicillin, vancomycin and imipenem was ultimately successful in suppressing enterococcal bacteremia. The enhanced activity of this triple combination was documented by the results of serial serum bactericidal titers.
MeSH terms
-
Adult
-
Ampicillin / pharmacology
-
Ampicillin / therapeutic use
-
Anti-Bacterial Agents / pharmacology
-
Anti-Bacterial Agents / therapeutic use
-
Bacteremia / drug therapy*
-
Drug Resistance, Microbial
-
Drug Therapy, Combination / pharmacology
-
Drug Therapy, Combination / therapeutic use*
-
Enterococcus faecalis / drug effects*
-
Enterococcus faecalis / isolation & purification
-
Female
-
Gentamicins / pharmacology
-
Gentamicins / therapeutic use
-
Gram-Positive Bacterial Infections / drug therapy*
-
Humans
-
Imipenem / pharmacology
-
Imipenem / therapeutic use
-
Penicillins / pharmacology
-
Penicillins / therapeutic use
-
Serum Bactericidal Test
-
Thienamycins / pharmacology
-
Thienamycins / therapeutic use
-
Vancomycin / pharmacology
-
Vancomycin / therapeutic use
Substances
-
Anti-Bacterial Agents
-
Gentamicins
-
Penicillins
-
Thienamycins
-
Vancomycin
-
Imipenem
-
Ampicillin