Abstract
The combination of ampicillin and ciprofloxacin displayed bactericidal in-vitro activity against two strains of Enterococcus faecium which were highly resistant to ampicillin, vancomycin, and aminoglycosides. This antibiotic combination was used to treat rabbits with experimental endocarditis caused by these strains. Although a significant decrease in vegetation bacterial counts occurred with one strain, the degree of killing did not approach that of penicillin with an aminoglycoside against susceptible enterococci.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ampicillin / therapeutic use
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Animals
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Anti-Infective Agents / therapeutic use
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Ciprofloxacin / therapeutic use
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Drug Resistance, Multiple
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Drug Therapy, Combination / therapeutic use*
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Enterococcus faecium*
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Gram-Positive Bacterial Infections / drug therapy*
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Gram-Positive Bacterial Infections / microbiology
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Humans
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Kidney / microbiology
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Microbial Sensitivity Tests
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Penicillins / therapeutic use
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Rabbits
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Spleen / microbiology
Substances
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Anti-Infective Agents
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Penicillins
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Ciprofloxacin
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Ampicillin