In vitro activity of RP 74501-RP 74502, a novel streptogramin antimicrobial mixture, against clinical isolates of Legionella species

Antimicrob Agents Chemother. 1993 Apr;37(4):908-10. doi: 10.1128/AAC.37.4.908.

Abstract

Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active than the same erythromycin concentration in a macrophage system for both L. pneumophila strains studied but at a lower concentration (0.25 microgram/ml) was much less active than erythromycin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Colony Count, Microbial
  • Erythromycin / pharmacology
  • Guinea Pigs
  • Legionella / drug effects*
  • Legionellosis / microbiology*
  • Macrophages, Alveolar / drug effects
  • Macrophages, Alveolar / microbiology
  • Virginiamycin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Virginiamycin
  • Erythromycin