Penetration of fusidic acid into human brain tissue and cerebrospinal fluid

Acta Neurochir (Wien). 1993;121(1-2):12-4. doi: 10.1007/BF01405176.

Abstract

Penetration of fusidic acid into brain tissue in six patients and cerebrospinal fluid in seven patients was determined. Tissue samples, taken during surgery revealed drug levels at about 7% of simultaneous serum concentrations. In contrast, cerebrospinal fluid concentrations were below 1% of serum levels. Since serum- and tissue levels of fusidic acid were far above the minimal inhibitory concentration (MICs) of staphylococci and streptococci, and since it has a long serum half-life of about 10 hours, it is a promising candidate for prophylaxis in neurosurgery.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Blood-Brain Barrier / physiology*
  • Brain / metabolism*
  • Brain Diseases / blood
  • Brain Diseases / surgery*
  • Brain Neoplasms / blood
  • Brain Neoplasms / surgery
  • Cerebral Cortex / metabolism
  • Double-Blind Method
  • Female
  • Fusidic Acid / administration & dosage
  • Fusidic Acid / pharmacokinetics*
  • Humans
  • Male
  • Middle Aged
  • Premedication*
  • Prospective Studies
  • Surgical Wound Infection / blood
  • Surgical Wound Infection / prevention & control*

Substances

  • Fusidic Acid