Relative resistance to erythromycin in Chlamydia trachomatis

Antimicrob Agents Chemother. 1980 Nov;18(5):696-8. doi: 10.1128/AAC.18.5.696.

Abstract

Recent Chlamydia trachomatis isolates were tested in a tissue culture system for susceptibility to tetracycline, erythromycin, rosaramicin, rifampin, and clindamycin. Rifampin was the most active drug (minimal inhibitory concentration, less than or equal to 0.02 microgram/ml). Tetracycline and rasaramicin were highly active, with a concentration of less than or equal to 0.25 microgram/ml being chlamydicidal. Clindamycin was least active on a weight basis, requiring up to 16 microgram/ml to prevent the passage of chlamydiae into a drug-free tissue culture system. Relative resistance to erythromycin was detected; two isolates were capable of limited replication in 1 microgram/ml.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Chlamydia Infections / microbiology
  • Chlamydia trachomatis / drug effects*
  • Drug Resistance, Microbial
  • Erythromycin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Erythromycin