Identification of staphylococcal Panton-Valentine leukocidin as a potent dermonecrotic toxin

Infect Immun. 1980 May;28(2):393-7. doi: 10.1128/iai.28.2.393-397.1980.

Abstract

The Panton-Valentine leukocidin of Staphylococcus aureus was shown to exhibit a potent dermonecrotic effect when injected intradermally into rabbits. This effect could be abrogated by immunizing animals with the F component or both components, but immunization with the S component appeared to exacerbate certain of the intradermal responses.

MeSH terms

  • Animals
  • Immune Sera
  • Immunization
  • Intradermal Tests
  • Leukocidins / pharmacology*
  • Necrosis
  • Rabbits
  • Skin / pathology
  • Staphylococcus aureus / immunology*
  • Toxins, Biological / immunology*
  • Toxins, Biological / pharmacology

Substances

  • Immune Sera
  • Leukocidins
  • Toxins, Biological