Interaction between vancomycin and rifampin against Staphylococcus aureus

Antimicrob Agents Chemother. 1981 Jun;19(6):1089-91. doi: 10.1128/AAC.19.6.1089.

Abstract

By the time-kill method, vancomycin and rifampin were antagonistic against 43 of 50 strains of Staphylococcus aureus, whether susceptible or resistant to methicillin.

MeSH terms

  • Drug Interactions
  • Drug Therapy, Combination
  • Humans
  • Methicillin / pharmacology
  • Microbial Sensitivity Tests
  • Rifampin / pharmacology*
  • Staphylococcal Infections / drug therapy
  • Staphylococcus aureus / drug effects*
  • Vancomycin / pharmacology*

Substances

  • Vancomycin
  • Methicillin
  • Rifampin