Safety of oral vancomycin in functionally anephric patients

Antimicrob Agents Chemother. 1978 Oct;14(4):634-5. doi: 10.1128/AAC.14.4.634.

Abstract

Administration of a vancomycin oral solution, 2 g daily for 16 days, to functionally anephric patients without inflammatory bowel disease resulted in assayable but low (</=0.66 mug/ml) serum levels in two of the five volunteers.

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Aluminum / pharmacology
  • Antacids / pharmacology
  • Carbonates / pharmacology
  • Drug Interactions
  • Humans
  • Kidney Failure, Chronic / metabolism*
  • Male
  • Middle Aged
  • Vancomycin / administration & dosage
  • Vancomycin / metabolism*

Substances

  • Antacids
  • Carbonates
  • Vancomycin
  • Aluminum