Mutants of Escherichia coli that are resistant to certain beta-lactam compounds lack the ompF porin

Antimicrob Agents Chemother. 1981 Oct;20(4):549-52. doi: 10.1128/AAC.20.4.549.

Abstract

Carbenicillin-resistant mutants of Escherichia coli K-12 and B/r were found to produce greatly diminished levels of the porin coded by the ompF gene. Physiological and ecological implications of these findings are discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Outer Membrane Proteins
  • Carbenicillin / pharmacology
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli / metabolism
  • Genes, Bacterial
  • Membrane Proteins / biosynthesis*
  • Mutation*
  • Penicillin Resistance

Substances

  • Anti-Bacterial Agents
  • Bacterial Outer Membrane Proteins
  • Membrane Proteins
  • Carbenicillin