Abstract
A penicillin-aminoglycoside regimen is accepted therapy for enterococcal endocarditis, but use of combinations of antibiotics in other forms of bacterial endocarditis is controversial. This review analyzes in-vitro, experimental animal model, and clinical studies of combination "synergistic" antibiotic treatment for enterococcal, viridans streptococcal, staphylococcal, and gram-negative aerobic bacillary endocarditis. Current recommendations for treatment of these entities are discussed.
MeSH terms
-
Aminoglycosides / administration & dosage
-
Animals
-
Anti-Bacterial Agents / administration & dosage*
-
Disease Models, Animal
-
Drug Therapy, Combination
-
Endocarditis, Bacterial / drug therapy*
-
Endocarditis, Bacterial / etiology
-
Gentamicins / administration & dosage
-
Humans
-
Penicillins / administration & dosage
-
Pseudomonas Infections / drug therapy
-
Staphylococcal Infections / drug therapy
-
Streptococcal Infections / drug therapy
-
Streptomycin / administration & dosage
-
Vancomycin / administration & dosage
Substances
-
Aminoglycosides
-
Anti-Bacterial Agents
-
Gentamicins
-
Penicillins
-
Vancomycin
-
Streptomycin