Quinine loading dose in cerebral malaria

Am J Trop Med Hyg. 1983 Jan;32(1):1-5. doi: 10.4269/ajtmh.1983.32.1.

Abstract

In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain Diseases / drug therapy*
  • Female
  • Humans
  • Infusions, Parenteral
  • Malaria / drug therapy*
  • Male
  • Mathematics
  • Plasmodium falciparum
  • Quinine / administration & dosage*
  • Quinine / adverse effects
  • Quinine / blood

Substances

  • Quinine