Salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole

Lancet. 1981 May 30;1(8231):1181-3. doi: 10.1016/s0140-6736(81)92350-3.

Abstract

Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chloramphenicol / pharmacology*
  • DNA Transposable Elements / drug effects
  • Drug Combinations / pharmacology
  • Drug Resistance, Microbial
  • Feces / microbiology
  • Female
  • Humans
  • Plasmids / drug effects
  • Salmonella typhi / classification
  • Salmonella typhi / drug effects*
  • Sulfamethoxazole / pharmacology*
  • Trimethoprim / pharmacology*
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Urine / microbiology

Substances

  • DNA Transposable Elements
  • Drug Combinations
  • Chloramphenicol
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole