Abstract
Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient.
MeSH terms
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Adult
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Chloramphenicol / pharmacology*
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DNA Transposable Elements / drug effects
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Drug Combinations / pharmacology
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Drug Resistance, Microbial
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Feces / microbiology
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Female
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Humans
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Plasmids / drug effects
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Salmonella typhi / classification
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Salmonella typhi / drug effects*
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Sulfamethoxazole / pharmacology*
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Trimethoprim / pharmacology*
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Trimethoprim, Sulfamethoxazole Drug Combination
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Urine / microbiology
Substances
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DNA Transposable Elements
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Drug Combinations
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Chloramphenicol
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Trimethoprim, Sulfamethoxazole Drug Combination
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Trimethoprim
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Sulfamethoxazole