Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci

Antimicrob Agents Chemother. 1974 Oct;6(4):411-4. doi: 10.1128/AAC.6.4.411.

Abstract

Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 mug/ml inhibited six of 13 strains and, at 3 mug/ml, 10 of 13 strains.

MeSH terms

  • Doxycycline / pharmacology*
  • Methicillin Resistance / physiology*
  • Microbial Sensitivity Tests
  • Minocycline / pharmacology*
  • Staphylococcus / drug effects*
  • Tetracycline / pharmacology*

Substances

  • Tetracycline
  • Minocycline
  • Doxycycline