Pharmacokinetics of mezlocillin in patients with hepatobiliary dysfunction

J Antimicrob Chemother. 1986 Dec;18(6):709-13. doi: 10.1093/jac/18.6.709.

Abstract

The pharmacokinetics of mezlocillin were investigated in 26 patients with alcoholic liver disease. Serum concentrations of mezlocillin were measured following intravenous administration of 3 g doses over 30 min. The mean peak serum concentration (+/- standard deviation) of mezlocillin at the end of infusion was 138.8 +/- 55.7 mg/l and the mean terminal half-life (T 1/2 beta) was 2.10 +/- 0.9 h. The 24 h urinary recovery of mezlocillin was 35.4 +/- 12.4% of the administered dose. Serum clearance was found to be inversely correlated with alkaline phosphatase and with total bilirubin. The T 1/2 beta was related to the following clinical measurements: age, SGOT and prothrombin time. This relationship suggests it may be prudent to adjust the dosage and the dosage interval of mezlocillin in patients with hepatobiliary dysfunction.

MeSH terms

  • Adult
  • Aged
  • Biliary Tract Diseases / metabolism*
  • Female
  • Humans
  • Kinetics
  • Liver Diseases / metabolism*
  • Male
  • Mezlocillin / blood
  • Mezlocillin / metabolism*
  • Mezlocillin / urine
  • Middle Aged

Substances

  • Mezlocillin