Effect of roxithromycin on acute toxoplasmosis in mice

Antimicrob Agents Chemother. 1987 Jul;31(7):1147-9. doi: 10.1128/AAC.31.7.1147.

Abstract

Roxithromycin effectively treated acute peritoneal murine toxoplasmosis. After five doses, starting 24 h after challenge, the 100 and 50% survival doses were 540 and 336 mg/kg per day, respectively. After 14 doses, starting 3 h after challenge, the 50% survival dose was 360 mg/kg per day. Toxoplasma gondii was recovered from the brain in 59 and 28% of surviving mice treated with 5 and 14 doses, respectively.

MeSH terms

  • Acute Disease
  • Animals
  • Disease Models, Animal
  • Female
  • Leucomycins / therapeutic use*
  • Mice
  • Random Allocation
  • Toxoplasmosis, Animal / drug therapy*

Substances

  • Leucomycins