Albendazole and thiabendazole in murine strongyloidiasis

J Antimicrob Chemother. 1987 Jan;19(1):79-85. doi: 10.1093/jac/19.1.79.

Abstract

The activity of albendazole and thiabendazole, two derivatives of benzimidazole, were tested in an experimental model of Strongyloides ratti infestation in the rat. Two series of seven consecutive daily negative parasitic plate cultures, separated by four weeks of steroid therapy, confirmed cure of the infestation. Both drugs were inactive against larvae in the tissue phase, but completely effective in the intestinal phase.

MeSH terms

  • Albendazole
  • Animals
  • Anthelmintics / therapeutic use*
  • Benzimidazoles / therapeutic use*
  • Female
  • Larva / drug effects
  • Rats
  • Rats, Inbred Strains
  • Strongyloides / drug effects
  • Strongyloidiasis / drug therapy*
  • Thiabendazole / therapeutic use*

Substances

  • Anthelmintics
  • Benzimidazoles
  • Albendazole
  • Thiabendazole