Abstract
A mouse model of cerebral nocardiosis was used to determine relative antibiotic efficacy by reducing bacterial colony counts per gram of brain tissue. The antimicrobial agents employed were demonstrated in vitro to be inhibitory to most strains of Nocardia asteroides at very low concentrations. The agents used in this study were imipenem-cilastatin, amikacin, trimethoprim-sulfamethoxazole, and minocycline. Antibiotics were administered every 4 h for 72 h before animal sacrifice. Bacterial colony counts were assayed at various time points before the completion of therapy. Imipenem-cilastatin and amikacin were the most effective agents tested. Trimethoprim-sulfamethoxazole was less effective than imipenem and amikacin but more effective than minocycline. Minocycline did not eradicate intracerebral organisms and was similar to saline (control) in its effects.
MeSH terms
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Amikacin / metabolism
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Amikacin / pharmacology
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Amikacin / therapeutic use*
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Animals
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Brain Diseases / drug therapy*
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Drug Combinations / metabolism
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Drug Combinations / pharmacology
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Drug Combinations / therapeutic use
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Female
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Imipenem
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Kinetics
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Mice
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Minocycline / metabolism
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Minocycline / pharmacology
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Minocycline / therapeutic use*
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Nocardia Infections / drug therapy*
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Nocardia asteroides / drug effects
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Sulfamethoxazole / metabolism
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Sulfamethoxazole / pharmacology
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Sulfamethoxazole / therapeutic use*
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Tetracyclines / therapeutic use*
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Thienamycins / metabolism
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Thienamycins / pharmacology
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Thienamycins / therapeutic use*
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Trimethoprim / metabolism
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Trimethoprim / pharmacology
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Trimethoprim / therapeutic use*
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Trimethoprim, Sulfamethoxazole Drug Combination
Substances
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Drug Combinations
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Tetracyclines
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Thienamycins
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Imipenem
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Trimethoprim, Sulfamethoxazole Drug Combination
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Amikacin
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Trimethoprim
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Minocycline
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Sulfamethoxazole