The treatment of donovanosis (granuloma inguinale)

Sex Transm Dis. 1988 Jan-Mar;15(1):27-9. doi: 10.1097/00007435-198801000-00006.

Abstract

Over a two-year period, 37 patients with genital ulcer disease attending a clinic for sexually transmitted diseases in Harare were found to have donovanosis. Of the 37 patients, 25 were male, and 12 were female; all presented with painless, indurated, granulating ulcers without lymph-node involvement. The lesions were more extensive in pregnant women. All patients responded well to either a combination of intramuscular streptomycin plus oral tetracycline given over 14 days, or a 14-day course of oral co-trimoxazole (trimethoprim-sulfamethoxazole). No metastatic lesions were found.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Granuloma Inguinale / diagnosis
  • Granuloma Inguinale / drug therapy*
  • Granuloma Inguinale / pathology
  • Humans
  • Male
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Streptomycin / therapeutic use*
  • Sulfamethoxazole / administration & dosage
  • Sulfamethoxazole / therapeutic use*
  • Tetracycline / therapeutic use*
  • Trimethoprim / administration & dosage
  • Trimethoprim / therapeutic use*

Substances

  • Trimethoprim
  • Tetracycline
  • Sulfamethoxazole
  • Streptomycin