Susceptibility of Pseudomonas pseudomallei to new beta-lactam and aminoglycoside antibiotics

J Antimicrob Chemother. 1988 Feb;21(2):171-5. doi: 10.1093/jac/21.2.171.

Abstract

Pseudomonas pseudomallei is resistant to many antimicrobial agents. We determined the susceptibility to twelve beta-lactams and six aminoglycosides of twelve isolates of P. pseudomallei. Imipenem (MIC range 0.5-1.0 mg/l; MIC90 1.0 mg/l), ceftazidime (MIC range 1-8 mg/l; MIC90 8.0 mg/l), amoxycillin/clavulanate (MIC range 4-8 mg/l; MIC90 8.0 mg/l), piperacillin (MIC range 4-16 mg/l; MIC90 8.0 mg/l), and carumonam (MIC range 4-16 mg/l; MIC90 8.0 mg/l) were the most active. Aminoglycosides were relatively inactive, for example, gentamicin (MIC range 16-64 mg/l; MIC90 64 mg/l), netilmicin (MIC range 16-128 mg/l; MIC90 128 mg/l) and amikacin (MIC range 32-64 mg/l; MIC90 64 mg/l).

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / pharmacology*
  • Humans
  • Imipenem
  • Melioidosis / drug therapy
  • Microbial Sensitivity Tests
  • Pseudomonas / drug effects*
  • Thienamycins / pharmacology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Thienamycins
  • Imipenem