In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii

Antimicrob Agents Chemother. 1987 Feb;31(2):346-8. doi: 10.1128/AAC.31.2.346.

Abstract

We investigated the activity of roxithromycin (RU 965) and gamma interferon alone and in combination in a murine model of toxoplasmic encephalitis. Roxithromycin at a dosage of 35 or 50 mg per mouse per day decreased mortality. Gamma interferon alone significantly prolonged time to death. When combined, the two agents were remarkably synergistic.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animal Feed
  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Synergism
  • Drug Therapy, Combination
  • Encephalitis / drug therapy*
  • Female
  • Interferon-gamma / therapeutic use*
  • Leucomycins / therapeutic use*
  • Mice
  • Toxoplasmosis, Animal / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Leucomycins
  • Interferon-gamma