In vitro activity of minocycline and rifampin against staphylococci

Diagn Microbiol Infect Dis. 1989 May-Jun;12(3):253-5. doi: 10.1016/0732-8893(89)90022-9.

Abstract

We tested the in vitro inhibitory and bactericidal activity of minocycline against 26 methicillin-susceptible Staphylococcus aureus, 24 methicillin-resistant S. aureus, 1 methicillin-susceptible coagulase-negative staphylococci, and 33 methicillin-resistant coagulase-negative staphylococci. Minocycline and rifampin had MIC90 results in the susceptible range, but MBCs were markedly elevated for minocycline alone (MBC50 greater than 32 micrograms/ml). The combination of minocycline and rifampin was synergistic for 30% of the isolates with the highest rates of synergy being against methicillin-resistant isolates.

MeSH terms

  • Drug Synergism
  • Microbial Sensitivity Tests
  • Minocycline / pharmacology*
  • Rifampin / pharmacology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification
  • Tetracyclines / pharmacology*

Substances

  • Tetracyclines
  • Minocycline
  • Rifampin