Abstract
A case of Nocardia asteroides pneumonia in a patient with the acquired immunodeficiency syndrome who was intolerant of sulfadiazine is described. On cefuroxime, the patient had a complete resolution of his Nocardia pneumonia. Disk-diffusion and broth microdilution antibiotic susceptibility testing (MIC less than or equal to 2 micrograms/ml) strongly supported the use of cefuroxime as treatment in this patient. Susceptibility testing with newer cephalosporins should be considered for all significant Nocardia isolates.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications*
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Adult
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Cefuroxime / pharmacology
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Cefuroxime / therapeutic use*
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Cephalosporins / therapeutic use*
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Humans
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Male
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Microbial Sensitivity Tests
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Nocardia Infections / complications*
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Nocardia Infections / drug therapy
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Nocardia asteroides / drug effects
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Nocardia asteroides / isolation & purification
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Opportunistic Infections / complications*
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Opportunistic Infections / drug therapy
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Pneumonia / complications*
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Pneumonia / drug therapy
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Sputum / microbiology
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Sulfadiazine / adverse effects
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Sulfadiazine / therapeutic use
Substances
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Cephalosporins
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Sulfadiazine
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Cefuroxime