Use of antimicrobial agents in renal failure

Infect Dis Clin North Am. 1989 Sep;3(3):517-31.

Abstract

Many antimicrobial agents are excreted primarily by the kidneys, and hence, to avoid toxicity and maintain efficacy, dosage adjustments are necessary. After estimating a patient's creatinine clearance, an appropriate dosage adjustment is easily accomplished. The adjustments for aminoglycosides are simplified by the use of a suggested once-daily, or once every other day dosage regimen.

Publication types

  • Review

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / therapeutic use*
  • Creatinine / blood
  • Creatinine / urine
  • Female
  • Humans
  • Kidney / physiopathology
  • Kidney Failure, Chronic / drug therapy*
  • Kidney Failure, Chronic / metabolism
  • Kidney Failure, Chronic / therapy
  • Male
  • Renal Dialysis

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Creatinine