Abstract
Many antimicrobial agents are excreted primarily by the kidneys, and hence, to avoid toxicity and maintain efficacy, dosage adjustments are necessary. After estimating a patient's creatinine clearance, an appropriate dosage adjustment is easily accomplished. The adjustments for aminoglycosides are simplified by the use of a suggested once-daily, or once every other day dosage regimen.
MeSH terms
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Aminoglycosides
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / therapeutic use*
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Creatinine / blood
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Creatinine / urine
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Female
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Humans
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Kidney / physiopathology
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Kidney Failure, Chronic / drug therapy*
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Kidney Failure, Chronic / metabolism
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Kidney Failure, Chronic / therapy
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Male
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Renal Dialysis
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Creatinine