Abstract
The uptakes of norfloxacin by quinolone-resistant and -susceptible strains of Serratia marcescens were almost the same and 50% inhibitory concentrations for DNA gyrase and the MICs of quinolones were correlated, suggesting that DNA gyrase alterations are the basis of quinolone resistance.
MeSH terms
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Anti-Infective Agents / pharmacology*
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Bacterial Outer Membrane Proteins / analysis
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DNA Topoisomerases, Type II / metabolism
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Drug Resistance, Microbial
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Electrophoresis, Polyacrylamide Gel
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Enterobacteriaceae Infections / microbiology
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Humans
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Microbial Sensitivity Tests
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Norfloxacin / metabolism
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Serratia marcescens / drug effects*
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Serratia marcescens / enzymology
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Serratia marcescens / metabolism
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Urinary Tract Infections / microbiology
Substances
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Anti-Infective Agents
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Bacterial Outer Membrane Proteins
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DNA Topoisomerases, Type II
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Norfloxacin