Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary care medical center

Darowan S Akajagbor; Sharon L Wilson; Kapana D Shere-Wolfe; Paul Dakum; Manhattan E Charurat; Bruce L Gilliam

doi:10.1093/cid/cit453

Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary care medical center

Clin Infect Dis. 2013 Nov;57(9):1300-3. doi: 10.1093/cid/cit453. Epub 2013 Jul 9.

Authors

Darowan S Akajagbor¹, Sharon L Wilson, Kapana D Shere-Wolfe, Paul Dakum, Manhattan E Charurat, Bruce L Gilliam

Affiliation

¹ Department of Pharmacy Practice, D'Youville College School of Pharmacy, Buffalo.

PMID: 23840000
DOI: 10.1093/cid/cit453

Abstract

Nephrotoxicity was assessed in 173 critically ill patients receiving intravenous colistin or polymyxin B; it occurred in 60.4% and 41.8%, respectively. Further investigation is necessary to elucidate the reason for the difference in nephrotoxicity observed between the groups and to assess the impact of severity of illness and dosing/administration.

Keywords: AKI; PB; colistimethate sodium; colistin; nephrotoxicity.

MeSH terms

Acute Kidney Injury / chemically induced*
Acute Kidney Injury / epidemiology*
Administration, Intravenous
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / adverse effects*
Cohort Studies
Colistin / administration & dosage
Colistin / adverse effects
Colistin / analogs & derivatives*
Critical Illness
Female
Humans
Incidence
Male
Middle Aged
Polymyxin B / administration & dosage
Polymyxin B / adverse effects*
Retrospective Studies
Tertiary Care Centers

Substances

Anti-Bacterial Agents
colistinmethanesulfonic acid
Polymyxin B
Colistin