Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin

Clin Infect Dis. 2013 Feb;56(3):420-2. doi: 10.1093/cid/cis918. Epub 2012 Nov 1.

Abstract

Persistent nontreponemal titers after treatment are common among patients with early syphilis. We retreated 82 human immunodeficiency virus-negative early syphilis participants who were serofast at 6 months using benzathine penicillin. Only 27% exhibited serological response after retreatment and after an additional 6 months of follow-up.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Penicillin G Benzathine / therapeutic use*
  • Retreatment
  • Syphilis / drug therapy*
  • Syphilis Serodiagnosis
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Penicillin G Benzathine