Growing prevalence of Providencia stuartii associated with the increased usage of colistin at a tertiary health care center

Int J Infect Dis. 2012 Sep;16(9):e646-8. doi: 10.1016/j.ijid.2012.05.1029. Epub 2012 Jul 19.

Abstract

From 2005 to 2009, at Detroit Medical Center, the prevalence of Providencia stuartii increased from 0.52 to 0.91/1000 patient-days (p<0.001). The use of colistin also increased (p<0.001) during the study period. The increase in the prevalence of P. stuartii was associated with an increased use of colistin (p<0.001). Facilities that frequently use colistin and tigecycline should closely monitor the prevalence of P. stuartii along with other Proteeae, since these organisms are intrinsically resistant to colistin and tigecycline.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / adverse effects
  • Colistin / administration & dosage*
  • Colistin / adverse effects
  • Drug Resistance, Multiple, Bacterial
  • Enterobacteriaceae Infections / drug therapy
  • Enterobacteriaceae Infections / epidemiology*
  • Female
  • Humans
  • Logistic Models
  • Michigan / epidemiology
  • Middle Aged
  • Minocycline / administration & dosage
  • Minocycline / adverse effects
  • Minocycline / analogs & derivatives
  • Prevalence
  • Providencia / isolation & purification*
  • Retrospective Studies
  • Tertiary Care Centers
  • Tigecycline

Substances

  • Anti-Bacterial Agents
  • Tigecycline
  • Minocycline
  • Colistin