Plasmid-mediated quinolone resistance in extended-spectrum-β-lactamase- and AmpC β-lactamase-producing Serratia marcescens in China

Antimicrob Agents Chemother. 2012 Aug;56(8):4529-31. doi: 10.1128/AAC.00493-12. Epub 2012 Jun 4.

Abstract

We investigated the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants and examined the association of these determinants with extended-spectrum β-lactamases (ESBLs) and/or plasmid-mediated AmpC β-lactamases (pAmpCs) in Serratia marcescens isolates in China. In this study, the presence of PMQR determinants was significantly related to the coproduction of ESBLs and/or pAmpCs (CTX-M-14, SHV-5, DHA-1, and ACT-1), among which CTX-M-14 was the most common gene type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics*
  • China
  • Ciprofloxacin / pharmacology
  • Drug Resistance, Multiple, Bacterial / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Ofloxacin / pharmacology
  • Plasmids* / genetics
  • Quinolones / pharmacology*
  • Serratia Infections / drug therapy
  • Serratia Infections / microbiology
  • Serratia marcescens / drug effects*
  • Serratia marcescens / genetics*
  • Serratia marcescens / isolation & purification
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Quinolones
  • Ciprofloxacin
  • Ofloxacin
  • beta-lactamase CTX-M-14
  • AmpC beta-lactamases
  • beta-Lactamases