In-vitro comparison of the post-antibiotic effect of vancomycin and teicoplanin

J Antimicrob Chemother. 1990 Aug;26(2):203-7. doi: 10.1093/jac/26.2.203.

Abstract

The post-antibiotic effect (PAE) of teicoplanin was compared with that of vancomycin for five selected Gram-positive cocci. Two concentrations of each antibiotic were investigated, with the test organisms being exposed to each for both 1 and 2 h. At a concentration of 25 mg/l, teicoplanin had a greater PAE than vancomycin for the methicillin resistant staphylococci and Enterococcus faecalis strains tested. At a concentration of 5 mg/l, teicoplanin gave equal effects to those of vancomycin except for the strain of methicillin-resistant Staphylococcus aureus (MRSA) tested. The variation in the antibiotic exposure time gave only small changes in the PAE, except for the MRSA tested.

Publication types

  • Comparative Study

MeSH terms

  • Enterococcus faecalis / drug effects
  • Enterococcus faecalis / growth & development
  • Glycopeptides / pharmacology
  • Methicillin / pharmacology
  • Methicillin Resistance
  • Species Specificity
  • Staphylococcus / drug effects*
  • Staphylococcus / growth & development
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / growth & development
  • Staphylococcus epidermidis / drug effects
  • Staphylococcus epidermidis / growth & development
  • Teicoplanin
  • Time Factors
  • Vancomycin / pharmacology*

Substances

  • Glycopeptides
  • Teicoplanin
  • Vancomycin
  • Methicillin