Characteristics of NDM-1-producing Escherichia coli isolates that belong to the successful and virulent clone ST131

Antimicrob Agents Chemother. 2011 Jun;55(6):2986-8. doi: 10.1128/AAC.01763-10. Epub 2011 Mar 28.

Abstract

An NDM-1 carbapenemase-producing Escherichia coli isolate of sequence type 131 (ST131) that belonged to phylogenetic group B2 was obtained from a patient with a urinary tract infection who returned to the United States after a recent hospitalization while visiting India. NDM-1-producing E. coli ST131 had significantly more virulence factors than NDM-1-producing E. coli ST101, previously isolated from a patient in Canada. The presence of NDM β-lactamases in a very successful and virulent E. coli sequence type is of concern.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Escherichia coli / classification*
  • Escherichia coli / enzymology
  • Escherichia coli / pathogenicity
  • Humans
  • Male
  • Phylogeny
  • Polymerase Chain Reaction / methods
  • Urinary Tract Infections / microbiology
  • Virulence
  • beta-Lactamases / biosynthesis*

Substances

  • beta-Lactamases
  • beta-lactamase NDM-1