Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia

Eur J Clin Microbiol Infect Dis. 1991 Mar;10(3):207-10. doi: 10.1007/BF01964466.

Abstract

Mild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed that primaquine/clindamycin appears to be an equally effective alternative to trimethoprim/sulfamethoxazole. The spectrum of side-effects was similar for the two regimens; side-effects occurred with equal frequency but appeared to be less severe in patients given primaquine/clindamycin. Because therapy with primaquine and clindamycin was limited to patients with mild to moderate Pneumocystis carinii pneumonia, studies with this regimen in more severe cases are warranted.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Adult
  • Clindamycin / adverse effects
  • Clindamycin / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pneumonia, Pneumocystis / drug therapy*
  • Primaquine / adverse effects
  • Primaquine / therapeutic use*
  • Trimethoprim, Sulfamethoxazole Drug Combination / adverse effects
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use*

Substances

  • Clindamycin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Primaquine