Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii

Glenn A Pankuch; Harald Seifert; Peter C Appelbaum

doi:10.1016/j.diagmicrobio.2010.01.004

Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii

Diagn Microbiol Infect Dis. 2010 Jun;67(2):191-7. doi: 10.1016/j.diagmicrobio.2010.01.004. Epub 2010 Mar 24.

Authors

Glenn A Pankuch¹, Harald Seifert, Peter C Appelbaum

Affiliation

¹ Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.

PMID: 20338710
DOI: 10.1016/j.diagmicrobio.2010.01.004

Abstract

At 24 h, sub-MIC doripenem and levofloxacin showed synergy against 21 of 25 Pseudomonas aeruginosa strains, sub-MIC doripenem and amikacin against 22 isolates, and sub-MIC doripenem and colistin against 19 isolates. Of 25 Acinetobacter baumannii strains, sub-MIC doripenem and levofloxacin showed synergy against 11 strains at 24 h, sub-MIC doripenem and amikacin against 24 strains, and sub-MIC doripenem and colistin against all isolates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter Infections / microbiology
Acinetobacter baumannii / drug effects*
Acinetobacter baumannii / isolation & purification
Anti-Bacterial Agents / pharmacology*
Drug Synergism
Humans
Microbial Sensitivity Tests
Pseudomonas Infections / microbiology
Pseudomonas aeruginosa / drug effects*
Pseudomonas aeruginosa / isolation & purification

Substances

Anti-Bacterial Agents