Research and development of universal influenza vaccines

Microbes Infect. 2010 Apr;12(4):280-6. doi: 10.1016/j.micinf.2010.01.001. Epub 2010 Jan 15.

Abstract

The continuous threat of influenza pandemics determines the urgency and necessity to develop safe and effective vaccines against divergent influenza viruses. This review describes the advancements in the research and development of universal influenza vaccines based on the relatively conserved sequences of M2e, HA, and other proteins of influenza viruses.

Publication types

  • Review

MeSH terms

  • Biomedical Research / trends*
  • Conserved Sequence
  • Hemagglutinins, Viral / genetics
  • Hemagglutinins, Viral / immunology
  • Humans
  • Influenza Vaccines / genetics*
  • Influenza Vaccines / immunology*
  • Influenza, Human / epidemiology*
  • Influenza, Human / prevention & control*
  • Vaccines, Subunit / genetics
  • Vaccines, Subunit / immunology
  • Viral Matrix Proteins / genetics
  • Viral Matrix Proteins / immunology

Substances

  • Hemagglutinins, Viral
  • Influenza Vaccines
  • M2 protein, Influenza A virus
  • Vaccines, Subunit
  • Viral Matrix Proteins
  • hemagglutinin fusogenic peptide, influenza virus