Abstract
Rapid screening tests are insensitive for detecting the novel swine-origin influenza A (H1N1) virus (S-OIV), and false negatives can delay the diagnosis and initiation of appropriate antiviral therapy. The case of a 26-year-old double lung transplant recipient presenting with fever, bilateral pulmonary infiltrates, and a negative influenza direct immunofluorescent antibody on bronchoalveolar lavage is presented. A diagnosis was made, and antiviral therapy was started 10 days after the initial bronchoalveolar lavage on receipt of a positive culture for S-OIV. The published literature on the performance characteristics of rapid screening tests for S-OIV is reviewed in this clinical context.
MeSH terms
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Adult
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Antiviral Agents / therapeutic use
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Bronchoalveolar Lavage Fluid / virology
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Female
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Humans
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Immunocompromised Host
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Influenza A Virus, H1N1 Subtype / isolation & purification*
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Influenza, Human / diagnosis*
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Influenza, Human / drug therapy
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Influenza, Human / etiology*
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Influenza, Human / virology
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Lung Transplantation / adverse effects*
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Lung Transplantation / immunology
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Opportunistic Infections / diagnosis
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Opportunistic Infections / drug therapy
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Opportunistic Infections / etiology
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Opportunistic Infections / virology
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Oseltamivir / therapeutic use
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Pneumonia, Viral / diagnosis*
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Pneumonia, Viral / drug therapy
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Pneumonia, Viral / etiology*
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Pneumonia, Viral / virology
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Virology / methods*
Substances
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Antiviral Agents
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Oseltamivir