Novel swine-origin (S-OIV) H1N1 influenza A pneumonia in a lung transplant patient: a case report and review of the literature on performance characteristics of rapid screening tests for the S-OIV

Am J Med Sci. 2009 Dec;338(6):506-8. doi: 10.1097/MAJ.0b013e3181c78a64.

Abstract

Rapid screening tests are insensitive for detecting the novel swine-origin influenza A (H1N1) virus (S-OIV), and false negatives can delay the diagnosis and initiation of appropriate antiviral therapy. The case of a 26-year-old double lung transplant recipient presenting with fever, bilateral pulmonary infiltrates, and a negative influenza direct immunofluorescent antibody on bronchoalveolar lavage is presented. A diagnosis was made, and antiviral therapy was started 10 days after the initial bronchoalveolar lavage on receipt of a positive culture for S-OIV. The published literature on the performance characteristics of rapid screening tests for S-OIV is reviewed in this clinical context.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antiviral Agents / therapeutic use
  • Bronchoalveolar Lavage Fluid / virology
  • Female
  • Humans
  • Immunocompromised Host
  • Influenza A Virus, H1N1 Subtype / isolation & purification*
  • Influenza, Human / diagnosis*
  • Influenza, Human / drug therapy
  • Influenza, Human / etiology*
  • Influenza, Human / virology
  • Lung Transplantation / adverse effects*
  • Lung Transplantation / immunology
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / drug therapy
  • Opportunistic Infections / etiology
  • Opportunistic Infections / virology
  • Oseltamivir / therapeutic use
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / etiology*
  • Pneumonia, Viral / virology
  • Virology / methods*

Substances

  • Antiviral Agents
  • Oseltamivir