Abstract
The incidence of acute renal failure, defined by the risk, injury, or failure criteria of the RIFLE criteria (risk, injury, failure, loss, and end-stage kidney disease), in 66 patients who received colistimethate sodium was 45%, and 21% of patients stopped therapy because of nephrotoxicity. The RIFLE criteria should be used in the future to allow for comparison of nephrotoxicity among studies.
MeSH terms
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Adult
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Infections / drug therapy
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Colistin / administration & dosage
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Colistin / adverse effects*
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Colistin / analogs & derivatives
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Colistin / therapeutic use*
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Female
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Humans
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Incidence
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Injections, Intravenous
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Male
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Renal Insufficiency / chemically induced*
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United States
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Withholding Treatment
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Young Adult
Substances
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Anti-Bacterial Agents
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colistinmethanesulfonic acid
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Colistin