Voriconazole use for endemic fungal infections

Antimicrob Agents Chemother. 2009 Apr;53(4):1648-51. doi: 10.1128/AAC.01148-07. Epub 2009 Jan 12.

Abstract

In a retrospective review of 24 patients with histoplasmosis, blastomycosis, or coccidioidomycosis treated with voriconazole (most for salvage therapy), the outcome was favorable (improved or stable) for 22 (95.8%) within 2 months of starting voriconazole and for 20 (83.3%) at the last follow-up. Prospective studies are required to determine its role in the treatment of endemic mycoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antifungal Agents / therapeutic use*
  • Blastomycosis / drug therapy*
  • Coccidioidomycosis / drug therapy*
  • Female
  • Histoplasmosis / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Pyrimidines / therapeutic use*
  • Retrospective Studies
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole