Abstract
The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Colony Count, Microbial
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Cryoelectron Microscopy
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Enterococcus / drug effects*
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Enterococcus / ultrastructure*
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Glycopeptides / pharmacology*
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Lipoglycopeptides
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / ultrastructure*
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Vancomycin / pharmacology
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Vancomycin Resistance / drug effects*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Glycopeptides
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Lipoglycopeptides
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VanB protein, Enterococcus
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Vancomycin
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oritavancin