Transplantation-mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors

Liver Transpl. 2008 Dec;14(12):1803-9. doi: 10.1002/lt.21539.

Abstract

Transplantation-mediated alloimmune thrombocytopenia (TMAT) is donor-derived thrombocytopenia following solid-organ transplantation. To date, no clear consensus on the appropriateness of organ utilization from cadaver donors with a history of idiopathic thrombocytopenia purpura (ITP) has emerged. Herein is reported a devastating case of TMAT following liver transplantation utilizing an allograft from a donor with ITP that resulted in allograft failure. The literature is reviewed in this context to propose preliminary guidelines regarding utilization of allografts from cadaver donors with a history of ITP.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Cadaver
  • Hematoma / diagnostic imaging
  • Hepatitis C, Chronic / complications
  • Humans
  • Liver / diagnostic imaging
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / surgery*
  • Liver Cirrhosis / virology
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Postoperative Complications / etiology*
  • Postoperative Complications / immunology
  • Practice Guidelines as Topic*
  • Purpura, Thrombocytopenic, Idiopathic / diagnosis
  • Purpura, Thrombocytopenic, Idiopathic / immunology*
  • Purpura, Thrombocytopenic, Idiopathic / therapy
  • Radiography
  • Thrombocytopenia / etiology*
  • Thrombocytopenia / immunology
  • Tissue Donors*