Comparison of the activity of cefixime and activities of other oral antibiotics against adult clinical isolates of Moraxella (Branhamella) catarrhalis containing BRO-1 and BRO-2 and Haemophilus influenzae

Antimicrob Agents Chemother. 1991 Jan;35(1):192-4. doi: 10.1128/AAC.35.1.192.

Abstract

MICs of 10 oral antibiotics were determined for 105 Moraxella catarrhalis and 96 Haemophilus influenzae isolates from adults. A two- to fourfold increase in MICs of oral cephalosporins was seen in the presence of BRO-1 but not with TEM-1 or BRO-2. The MICs of cefixime for 90% of strains of H. influenzae (0.125 microgram/ml) and M. catarrhalis (0.25 microgram/ml) were 8- to 64-fold lower than those of other oral cephalosporins.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Amoxicillin / administration & dosage
  • Amoxicillin / pharmacology
  • Amoxicillin-Potassium Clavulanate Combination
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology*
  • Cefixime
  • Cefotaxime / administration & dosage
  • Cefotaxime / analogs & derivatives*
  • Cefotaxime / pharmacology
  • Cephalosporins / administration & dosage
  • Cephalosporins / pharmacology
  • Clavulanic Acids / administration & dosage
  • Clavulanic Acids / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination / administration & dosage
  • Drug Therapy, Combination / pharmacology
  • Erythromycin / administration & dosage
  • Erythromycin / pharmacology
  • Haemophilus influenzae / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Moraxella catarrhalis / drug effects*
  • Moraxella catarrhalis / enzymology
  • Tetracycline / administration & dosage
  • Tetracycline / pharmacology
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Clavulanic Acids
  • Erythromycin
  • Amoxicillin-Potassium Clavulanate Combination
  • Amoxicillin
  • Cefixime
  • beta-Lactamases
  • Tetracycline
  • Cefotaxime